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Abstract
The aim of the study is formulation and evaluation of herbal tablets from moringa oleifera leaves. Moringa oleifera leaves was extracted with ethanol and formulated by using different binders which included Gelatin, Micro-crystalline Cellulose (MCC), Maize Starch produced the best tablets of ethanol extract of Moringa oleifera leaves. Numerous criteria, including strength (friability, crushing strength), and release characteristics (disintegration and dissolution durations tests), were used to characterize the formulations. The outcome demonstrated that, in comparison to tablets made with MCC or maize starch, those made with gelatin as a binder had the lowest friability and disintegration time.
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References
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References
1. Ramachandran C, Peter KV, Gopalakrishnan PK. Drumstick (Moringa oleifera): A multi-purpose Indian vegetable. Econ Botany. 1980;34:276-283.
2. Adedapo AA, Mogbojuri OM, Emikpe BO. Safety evaluations of the aqueous extract of leaves of Moringa oleifera in rats. J Med Plants Res. 2009;3(8):586–591.3.
3. Faizi S, Siddiqui B, Saleem R, Siddiqui S, Aftab K. Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure. J Nat Prod. 1994;57:1256-1261.
4. Dillard CJ, German JB. Phytochemical, Nutraceuticals and human health. A Review. J Sci Food Agric. 2000; 80:1744-1756.
5. Abdulkarim SM, Long K, Lai OM, Mohammad SK, Ghazali HM. Some physiochemical properties of Moringa oleifera seed oil extracted using solvent and aqueous enzymatic methods. Food Chem 2005;93:253–63.
6. Xu YB, Chen GL, Guo MQ. Antioxidant and anti-inflammatory activities of the crude extracts of Moringa oleifera from Kenya and their correlations with flavonoids. Antioxidants (Basel). 2019;8:296. https://doi.org/10.3390/antiox8080296 PMid:31404978
7. Panche AN, Diwan AD, Chandra SR. Flavonoids: An overview. J Nutr Sci. 2016;5:e47. PMid:28620474
8. Nguyen TP, Tran CL, Vuong CH, Do TH, Le TD, Mai DT, et al. Flavonoids with hepatoprotective activity from the leaves of Cleome viscosa L. Nat Prod Res2017;31(22):2587-92. PMid :28135851
9. www.alibaba.com/showroom/moringa-powder.html. Accessed on June 6th 2012.
10. Rajesh A, Yadav N. Pharmaceutical Processing – A Review on Wet Granulation Technology. International Journal of Pharmaceutical Frontier Research.1 (1); 2011: 65-83.
11. Boerefijn R, Hounslow MJ. Studies of fluid bed granulation in an industrial R&D context. Chemical Engineering Science. 60; 2005: 3879-3890.
12. Ohwoavworhua FO, Adelakun TA, Kunle OO. A comparative evaluation of the Flow and Compaction characteristics of α-Cellulose obtained from Waste Paper. Tropical Journal of Pharmaceutical Research. 6(1); 2007: 645 – 651