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Abstract
Herbal drugs classification system represent as an important system of medicine for the treatment of a wide array of diseases. The medicinal plants from India provide a diverse source for health care moieties in order to prevent different pathological states. Alpinia officinarum, known as lesser galangal. Alpinia officinarum, a plant from ginger family.The paracetamol 640mg/kg BW P.O induced injuries of liver in animal are mostly used to screen out the hepatoprotective effect of extract. In the present study total phenolic and flavonoid contents, in vitro antioxidant, and in vivo hepatoprotective (on paracetamol induced intoxication in experimental male Sprague Rats) Potentials of the Alpinia officinarum rhizome ethanolic extract were determined. For the identification of possible phytochemical test. Glycoside, Phenol, Tannins, Steroids, Flavonoids were identified Alpinia officinarum extract at dose of 200mg/kg BW P.O and 400 mg/kg BW P.O were given for 14days to paracetamol intoxicated rats and observed results were compared with standard silymarin 50 mg/kg. The level of lever enzymes like aspartate aminotransferase, alanine aminotransferase, alkaline phosphate, total protein and total bilirubin. Furthermore histopathological analysis of the liver tissues of control and treated groups also confirmed hepatoprotective effect of the Alpinia officinarum which was most probably due to its high antioxidant phenolic and flavonoids phytoconstituents.
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References
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- 13. Tamas L, Huttová J, Mistrk I, Kogan G. Effect of carboxymethyl chitin-glucan on the activity of some hydrolytic enzymes in maize plants. Chem. Pap. 2002 Jan 1;56(5):326-9.
- 14. Li-Fern H, Rajasoorya C. The elevated serum alkaline phosphatase--the chase that led to two endocrinopathies and one possible unifying diagnosis. European journal of endocrinology. 1999 Feb;140(2):143-7.
- 15. Lange PH, Millan JL, Stigbrand T, Vessella RL, Ruoslahti E, Fishman WH. Placental alkaline phosphatase as a tumor marker for seminoma. Cancer research. 1982 Aug;42(8):3244- 7.
References
1. Tortora GJ, Derrickson BH. Principles of anatomy and physiology. John Wiley & Sons; 2018 May 15. 13th edition, Pp 990-995.
2. Kmiec Z. Cooperation of liver cells in health and disease: with 18 tables. 161:3-13, 1-151.
3. Waugh A, Grant A. Ross & Wilson Anatomy and physiology in health and illness E-book. Elsevier Health Sciences; 2014 Jun 25.
4. Mohan H. Textbook of pathology. Jaypee Brothers Medical Publishers; 2018 Nov 30.
5. Pickrell KD. Miller-Keane encyclopedia and dictionary of medicine, nursing, and allied health. Hospitals & Health Networks. 2003;77(8):70..
6. Wang CS, Chang TT, Yao WJ, Wang ST, Chou P. Impact of increasing alanine aminotransferase levels within normal range on incident diabetes. Journal of the Formosan Medical Association. 2012 Apr 1;111(4):201-8.
7. Ghouri N, Preiss D, Sattar N. Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease: a narrative review and clinical perspective of prospective data. Hepatology. 2010 Sep;52(3):1156-61.
8. Giboney PT. Mildly elevated liver transaminase levels in the asymptomatic patient. American family physician. 2005 Mar 15;71(6):1105-10.
9. Nyblom H, Berggren U, Balldin J, Olsson R. High AST/ALT ratio may indicate advanced alcoholic liver disease rather than heavy drinking. Alcohol and alcoholism. 2004 Jul 1;39(4):336-9.
10. Nyblom H, Björnsson E, Simrén M, Aldenborg F, Almer S, Olsson R. The AST/ALT ratio as an indicator of cirrhosis in patients with PBC. Liver International. 2006 Sep;26(7):840-5.
11. Hayashi H, Wada H, Yoshimura T, Esaki N, Soda K. Recent topics in pyridoxal 5'- phosphate enzyme studies. Annual review of biochemistry. 1990 Jul;59(1):87-110
12. Gaze DC. The role of existing and novel cardiac biomarkers for cardioprotection. Current opinion in investigational drugs. 2007;8(9):711-7.
13. Tamas L, Huttová J, Mistrk I, Kogan G. Effect of carboxymethyl chitin-glucan on the activity of some hydrolytic enzymes in maize plants. Chem. Pap. 2002 Jan 1;56(5):326-9.
14. Li-Fern H, Rajasoorya C. The elevated serum alkaline phosphatase--the chase that led to two endocrinopathies and one possible unifying diagnosis. European journal of endocrinology. 1999 Feb;140(2):143-7.
15. Lange PH, Millan JL, Stigbrand T, Vessella RL, Ruoslahti E, Fishman WH. Placental alkaline phosphatase as a tumor marker for seminoma. Cancer research. 1982 Aug;42(8):3244- 7.