Main Article Content
Abstract
The purpose of the study was To design, formulate and evaluate Colon Specific Delivery System tablets of Mesalamine which is effective in Management of Inflammatory Bowel Disease. The present work is aimed at preparation and evaluation of Colon Specific Delivery System tablets of Mesalamine using using HPMC K 100, Eudragit S 100 as polymers in varying ratios. The tablets were evaluated for its Thickness, Hardness, Friability, Friability, Disintegration and in vitro drug release studies. The FTIR studies revealed no chemical interaction between the drug molecule and polymers and found that drug was compatible with used polymer. In vitro drug release study confirms that formulation F9 was the best formulation as it releases 98.81 % at the end of 10 hr. This confirms the developed Mesalamine tablet is promising for Colon Specific Delivery System.
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References
- 1. Adrian H. Teruel, Isabel Gonzalez-Alvarez Marival Bermejo, Virginia Merino, Maria Dolores Marcos, Felix Sancenon, Marta Gonzalez-Alvarez, and Ramon Martinez-Mañez New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy Int J Mol Sci. 2020 Sep; 21(18): 6502.
- 2. Milad Reda Qelliny, Usama Farghly Aly, Omar Helmy Elgarhy, Khaled Aly khaled Colon Drug Delivery Systems for the Treatment of Inflammatory Bowel Disease J. Adv. Biomed. & Pharm. Sci. 2 (2019) 164-481
- 3. Sang Hoon Lee, Rajiv Bajracharya, Jeong Youn Min, Ji-Won Han, Byeong Ju Park, and Hyo-Kyung Han Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements 2020 Jan; 12(1): 68.
- 4. Nihar Ranjan Kar, Subas Chandra Dinda, Colon Specific Drug Delivery System: An Approach To Target Colonic Diseases January 2019 DOI:10.13040/IJPSR.0975-8232.10(3).1080-88
- 5. Yilin Guo, Shiyu Zong, Yiqiong Pu; Benliang Xu, Tong Zhang, and Bing Wang, Advances in Pharmaceutical Strategies Enhancing the Efficiencies of Oral Colon-Targeted Delivery Systems in Inflammatory Bowel Disease 2018, 23(7), 1622; https://doi.org/10.3390/molecules23071622
- 6. Yachao Ren, Lei Jiang, Shuman Yang, Sainan Gao, Hui Yu, Jie Hu1 Design and preparation of a novel colon-targeted tablet of hydrocortisone Brazilian Journal of Pharmaceutical Sciences, Braz. J. Pharm. Sci. 2017;53(1):e15009.
- 7. Hussain Mobarak, D. Biswajit, Chakraborty Jashabir Formulation, Optimization and Evaluation of Capecitabine Tablet for Colon Specific Drug Delivery System, DOI:10.25258/IJPCR.V9I7.8788 July 2017.
- 8. Boyd, M., Thodberg, M., Vitezic, M. et al. Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies. Nat Commun 9, 1661 (2018). https://doi.org/10.1038/s41467-018-03766-z
- 9. Vikas Jain, Ranjit Singh Design and Characterization of Colon-specific Drug Delivery System Containing Paracetamol Microsponges May 2011Archives of Pharmacal Research 34(5):733-40 DOI:10.1007/s12272-011-0506-4
- 10. K. R. Reddy, P. Swetha, author Vinay Kumar Formulation And Evaluation Of Colon Targeted Oral Drug Delivery System For Meloxicam International Journal Of Innovative Pharmaceutical Sciences And Research https://api.semanticscholar.org 2014
- 11. Samia A. Nour, Nevine Shawky Abdelmalak & Marianne J. Naguib (2015) Bumadizone calcium dihydrate microspheres compressed tablets for colon targeting: formulation, optimization and in vivo evaluation in rabbits, Drug Delivery, 22:3, 2
References
1. Adrian H. Teruel, Isabel Gonzalez-Alvarez Marival Bermejo, Virginia Merino, Maria Dolores Marcos, Felix Sancenon, Marta Gonzalez-Alvarez, and Ramon Martinez-Mañez New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy Int J Mol Sci. 2020 Sep; 21(18): 6502.
2. Milad Reda Qelliny, Usama Farghly Aly, Omar Helmy Elgarhy, Khaled Aly khaled Colon Drug Delivery Systems for the Treatment of Inflammatory Bowel Disease J. Adv. Biomed. & Pharm. Sci. 2 (2019) 164-481
3. Sang Hoon Lee, Rajiv Bajracharya, Jeong Youn Min, Ji-Won Han, Byeong Ju Park, and Hyo-Kyung Han Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements 2020 Jan; 12(1): 68.
4. Nihar Ranjan Kar, Subas Chandra Dinda, Colon Specific Drug Delivery System: An Approach To Target Colonic Diseases January 2019 DOI:10.13040/IJPSR.0975-8232.10(3).1080-88
5. Yilin Guo, Shiyu Zong, Yiqiong Pu; Benliang Xu, Tong Zhang, and Bing Wang, Advances in Pharmaceutical Strategies Enhancing the Efficiencies of Oral Colon-Targeted Delivery Systems in Inflammatory Bowel Disease 2018, 23(7), 1622; https://doi.org/10.3390/molecules23071622
6. Yachao Ren, Lei Jiang, Shuman Yang, Sainan Gao, Hui Yu, Jie Hu1 Design and preparation of a novel colon-targeted tablet of hydrocortisone Brazilian Journal of Pharmaceutical Sciences, Braz. J. Pharm. Sci. 2017;53(1):e15009.
7. Hussain Mobarak, D. Biswajit, Chakraborty Jashabir Formulation, Optimization and Evaluation of Capecitabine Tablet for Colon Specific Drug Delivery System, DOI:10.25258/IJPCR.V9I7.8788 July 2017.
8. Boyd, M., Thodberg, M., Vitezic, M. et al. Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies. Nat Commun 9, 1661 (2018). https://doi.org/10.1038/s41467-018-03766-z
9. Vikas Jain, Ranjit Singh Design and Characterization of Colon-specific Drug Delivery System Containing Paracetamol Microsponges May 2011Archives of Pharmacal Research 34(5):733-40 DOI:10.1007/s12272-011-0506-4
10. K. R. Reddy, P. Swetha, author Vinay Kumar Formulation And Evaluation Of Colon Targeted Oral Drug Delivery System For Meloxicam International Journal Of Innovative Pharmaceutical Sciences And Research https://api.semanticscholar.org 2014
11. Samia A. Nour, Nevine Shawky Abdelmalak & Marianne J. Naguib (2015) Bumadizone calcium dihydrate microspheres compressed tablets for colon targeting: formulation, optimization and in vivo evaluation in rabbits, Drug Delivery, 22:3, 2