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Aim: This study aimed to evaluate the antiparkinsonian activity of the hydroalcoholic extract of Ruellia tuberosa leaves in rats using suitable animal models.

Methods: The Ruellia tuberosa plant was collected from the market and authenticated. The leaves were dried, ground, and extracted with 90% v/v ethanol and distilled water. The phytochemical analysis was conducted using various tests. Catalepsy was induced in rats using Rotenone and HART was administered orally to the treatment group. The behavioral changes were assessed using the hole board test for catalepsy, motor coordination test by rotarod, and locomotor activity by actophotometer.

Results: The hydroalcoholic extract of Ruellia tuberosa (HART) showed antiparkinsonian activity in rats. The catalepsy induced by Rotenone was reduced in the treatment group, as observed in the hole board test and motor coordination test. The locomotor activity was also improved in the treatment group.

Conclusion: The findings of this study suggest that the hydroalcoholic extract of Ruellia tuberosa leaves possesses antiparkinsonian activity and could be a potential therapeutic agent for the treatment of Parkinson's disease. Further studies are needed to explore the mechanism of action and safety of this extract.


Ruellia tuberosa antiparkinsonian activity Rotenone HART

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Gayathri C, Tamilselvan G, & Senthil Kumar K L. (2024). Phytochemical Screening and Anti-Parkinsonian Activity of Hydroalcoholic Extract of the Ruellia Tuberosa Leaves in Rats. International Journal of Research in Pharmacology & Pharmacotherapeutics, 13(2), 63-68. Retrieved from


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