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Dec 15, 2023
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Dec 15, 2023
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Abstract

Background: Pediatric sepsis, sepsis syndromes and septic shock are significant causes of morbidity and mortality among children all over the globe and cause an alarming burden to patient care in Pediatric Intesnive Care Units (PICU). With mortality as high as 80% and relative paucity of epidemiological data regarding sepsis in children, there is need for large scale studies to evaluate various aetiologies,  risk factors and factors associated with poor outcome in children with various sepsis syndromes.


Objectives: To study the prevalence, assess the clinical profile, analyse the laboratory parameters and outcome in patients with septic shock admitted to PICU.


Methods: This prospective observational study was carried out between December 2019 and November 2021 in the PICU of a tertiary care hospital. All relevant clinical, laboratory and other data was collected from patients with septic shock aged between 1 month to 14-year.


Results: Among all the patients in PICU with shock, septic shock was diagnosed in 8.06% (n=85) cases, 44.5% (n=33) of them being infants. Mean age was 3 year 10 months with male preponderance. Most of them belonged to lower socioeconomic class (86.4%, n=64). Most common presenting symptom was abnormality of body temperature (87.8%, n=65). Incomplete immunization was observed in 43% (n=35). Pallor and anemia were present in almost 2/3rd of cases. Staphylococcus aureus was the most common organism isolated from culture of various body samples (47.6%, n=11). Most of the patients were fluid refractory (93.2%, n=65) and required vasopressor support, with 47% among these requiring ≥3 vasopressors. Need for corticosteroid use was associated with adverse outcomes. Various factors having significant association with mortality were inadequate immunisation, anemia, positive growth on blood culture, deranged renal and liver function tests, respiratory failure requiring mechanical ventilation, multi organ dysfunction, need for multiple vasopressors and administration of corticosteroids.


Conclusions: Successful management of pediatric septic shock requires good infrastructure, trained staff and protocol based management which may be modified from time to time basing upon constantly changing evidence-based medicine.

Keywords

sepsis syndrome pediatric critical care pediatric septic shock mortality septic shock pediatric intensive care unit etc

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Syed Almas Danish, Fara faizeen, Syeda Husna Sameen, Mohd Qasim Quadri, Madiha Tazeem, Sumeza Rahiya, & Zubeda Begum. (2023). A prospective study on outcomes for the septic shock in children admitted to a tertiary care hospital. International Journal of Research in Pharmacology & Pharmacotherapeutics, 12(4), 324-331. Retrieved from https://ijrpp.com/ijrpp/article/view/513
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