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Omeprazole is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. The Mucoadhesive buccal tablets were prepared by direct compression method using Sodium Alginate, HPMC K4M and SCMC as mucoadhesive polymer. The compatibility studies of drug and excipients were performed by FT-IR spectroscopy. After examining the flow properties of the powder blends the results are found to be within prescribed limits and indicated good flowing property, hence it was subjected to tablet compression. The tablets were evaluated for post compression parameters like weight variation, hardness, thickness, friability, drug content uniformity, Surface pH, in-vitro studies like drug release. Formulation (F4) containing HPMC K4M in the ratio of (1:1) showed maximum drug release of 99.54% in 8 hrs. The drug content of shown highest of 99.61 %, Surface pH was found to be 6.05. All the evaluation parameters given the positive results and comply with the standards. The results indicate that the mucoadhesive buccal tablets of Omeprazole may be good choice to bypass the extensive hepatic first pass metabolism with an improvement in the bioavailability of Omeprazole through buccal mucosa.


Omeprazole Sodium Alginate HPMC K4M SCMC and Buccal tablets

Article Details

How to Cite
Undru Purnima, T.K.V. Kesav Rao, & Raj Khiani. (2023). Formulation development and evaluation of omeprazole buccal tablets. International Journal of Research in Pharmacology & Pharmacotherapeutics, 12(3), 185-196.


  1. 1. V. T. Iswariya and A. Hari Om Prakash Rao. Buccal Tablets A Comprehensive Review. ejpmr, 2016,3(8), 252-262.
  2. 2. S.K.Gupta et al; Buccal adhesive drug delivery system: A review; Asian Journal Of Biochemical and pharmaceutical research, 2011;1(2): 105-114.
  3. 3. Reena Sheoran. Buccal Drug Delivery System: A Review. Int. J. Pharm. Sci. Rev. Res., 50(1), May - June 2018; Article No. 07, Pages: 40-46.
  4. 4. Wertz, P.W. and Squier, C.A., Cellular and molecular basis of barrier function in oral epithelium, Crit. Rev. Ther. Drug Carr. Sys, 8, 1991, 237-269.
  5. 5. Squier, C.A., Cox, P., and Wertz, P.W., Lipid content and water permeability of skin and oral mucosa, The J. Invest. Dermat, 96, 1991, 123-126.
  6. 6. Squier, C.A. and Wertz, P.W. Structure and function of the oral mucosa and implications for drug delivery, in eds. M.J. Rathbone, Oral Mucosal Drug Delivery, Marcel Dekker, Inc., New York, New York, 1996, 1-26.
  7. 7. Galey, W.R., Lonsdale, H.K., and Nacht, S., The in vitro permeability of skin and buccal mucosa to selected drugs and J Pharm Pharmaceut Sci ( 1 (1), 1998, 15-30.
  8. 8. Gandhi, R.B. and Robinson, J.R., Oral cavity as a site for bioadhesive drug delivery, Adv. Drug Del. Rev., 13, 1994, 43-74.
  9. 9. Peppas, N.A. and Buri, P.A., Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues, J.Control. Rel., 2, 1985, 257-275.
  10. 10. Duchene D, Touchard F and Peppas N A Pharmaceutical and medical aspects of Bioadhesive system for drug administration. Drug Dev. Ind. Pharm.; 14, 1998, 283-381.
  11. 11. Parth S. Patel ,Ashish M. Parmar, Nilang S. Doshi, Hardik V. Patel, Raxit R. Patel, Chetan Nayee. Buccal Drug Delivery System: A Review.
  12. 12. Webster’s Encyclopedic Unabridged Dictionary of the English Language. Thunder Bay Press, Avenel (NJ, USA), 2001.
  13. 13. Kaelbe D H and Moacanin J. A surface energy analysis of bioadhesion. Polym.; 18: 475-481, 1977.
  14. 14. Gu J M, Robinson J R and Leung S. binding of acrylic polymers to mucin/epithelial surfaces; Structure property-relationship. Crit. Rev. Ther. Drug Car. Sys.; 5, 21-67, 1998.
  15. 15. Duchene D, Touchard F and Peppas N A. Pharmaceutical and medical aspects of Bioadhesive system for drug administration. Drug Dev. Ind. Pharm.; 14, 283-381, 1998.
  16. 16. Hollingsbee D A and Timmins P. Topical adhesive system, in Bioadhesion Possibilities and Future Trends, Gurny R and Junginger H E Eds., Wissenchaftliche verlag Gesellschaft, Stuttgart; 140-164, 1990.
  17. 17. R. Jagadeeshwar Reddy, Maimuna Anjum and Mohammed Asif Hussain. A Comprehensive Review on Buccal Drug Delivery System. AJADD[1][3][2013]300-312.
  18. 18. Wise Donald L, Handbook of Pharmaceutical controlled release technology: 255-265.
  19. 19. Magi. L. et. al., (1994), S.T.P. Pharma Sciences, 4(5), 343.
  20. 20. Jimenez-Castellannos MR. Zia. H., Rhodes CT., (1993), Drug Dev. Ind Phar., 19(142), 143.