Articles

  1. Antimalarial efficacy of Nyctanthes arbor-tristis and its effect on combination with Artesunate in Plasmodium berghei K173 induced mice model. Download Article

    Ashwini Kumar Singh, Aniraban Pal, Hemant Kumar Dutt
    • Type: Research Article
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    • Pages (01-09)
    • No of Downloads: 92

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    Background

    Malaria is caused by parasite plasmodium species which is transmitted via the bite of infected mosquitoes, the key approach to treat malaria include prompt and effective treatment with Artemisinin based combination therapy. The search for additional antimalarial from plant extracts and their combination with Artemisinin derivatives must continue to help in effective treatment of the disease. 

    Aim

    To evaluate the antimalarial efficacy of Nyctanthes arbor-tristis (NAT) and its effect on combination with Artesunate. 

    Materials and Methods

    The study was done in the Department of Molecular Bioprospection, CSIR-CIMAP, Lucknow, Uttar Pradesh, India. Leaves of Nyctanthes arbor tristis (NAT) were chosen, dried, grounded and extracted with solvent of variable polarity. The bioactivity of NAT leaf extracts was carried out through Plasmodium berghei induced malaria in albino swiss mice animal model. The two independent experiments gave us the result to plan the third experiment on combination therapy. From the first experiment IC50 of Artesunate was derived and from the second experiment the Methanol 80% extract of NAT was found to be indicative of the plant bioactive. The experiment involving the combination therapy was taken up by combining 20mg/kg of Artesunate with 250mg/Kg and 500mg/Kg of Methanol 80% extract of NAT.

    Results

    Our study showed that by combining Methanol 80% extract of NAT with sub effective dose of Artesunate results in improvement of mean survival time, parasitaemia and haemoglobin levels.

    Conclusion

    Our experiment helped us to conclude that NAT leaves can be used as a lead for combination therapy. However, further detailed experiments related to the safety and pharmacokinetics of combination need to be considered.

  2. A questionnaire based study to assesss the attitude and perceptions of fifth term medical students at mahadevappa rampure medical college, Kalaburagi regarding teaching methods and learning in pharmacology Download Article

    Vallabhaneni Rajesh, Santoshkumar R. Jeevangi, Patil BV
    • Type: Research Article
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    • Pages (10-15)
    • No of Downloads: 11

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    Background

    Pharmacology, an integral subject of learning medical course, is progressing by enormously. Consequently, changes in undergraduate teaching are the need of the hour.

    Objectives

    To determine the medical students’ perception and receive feedback on teaching and learning of pharmacology in our institution.

    Material and Methods

    This was a cross-sectional study based on the questionnaire. A pre-validated, predesigned questionnaire containing 14 points was administered to fifth term medical students. Second year students were enrolled for the study at their end of 5th term before university exams.

    Results

    77% wanted the faculty members to make more use of Audio-Visual aids for effective learning. 70% of the students opined that Discussion of graphs   has helped us in better understanding of mechanism of action of the drugs. 20% of the students were willing to consider pharmacology as one of the subjects for post-graduation.73% of the students agreed that pictures showing the adverse drug reactions and their Clinical correlation explained with LCD projector lectures were more interesting.

    Conclusion

    The results of our study revealed a positive feedback from students which will help in making the teaching program in pharmacology more encouraging.

  3. Ulceroprotective effect of ethanolic extract of aegle marmelos leaves in wistar rats Download Article

    Saranya R, Sumitha A, Padmavathi S, Dhananjay S Kotasthane, Manimekalai K
    • Type: Research Article
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    • Pages (16-22)
    • No of Downloads: 60

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    Title

    Ulceroprotective effect of ethanolic extract of Aegle marmelos leaves in wistar rats..

    Objectives

     To evaluate the Ulceroprotective effect of ethanolic extract of Aegle marmelos leaves in wistar albino rats.

    Materials & Methods

     The study was conducted in 24 male adult wistar albino rats weighing 150-200g. 24 rats were randomized into 4 groups and ulceroprotective property of the extract was studied employing indomethacin induced ulcer model. Groups 1 & 2 were the normal and ulcer control respectively .Groups 3 and 4 were pretreated with misoprostol and extract (200mg/kg) respectively for 5 days followed by ulcer induction in groups 2, 3 and 4. Ulceroprotective activity was expressed as Percentage inhibition (PI). Statistical analysis was performed by one-way ANOVA followed by Tukey’s post-hoc test for multiple comparisons. p < 0.05 was considered to indicate statistical significance.

    Results

    The result data indicated that, mean ulcer index was significantly lower in the leaf extract pretreated group [Group 4 (5.175±0.05)] compared to control group with a PI of 50%. Histopathological examination confirmed the ulceroprotective activity of the extract evident from the reduction in number and severity of gastric ulcers

    Conclusion

    Based on the above findings it can be inferred that ethanolic extract of Aegle marmelos leaf extract has ulceroprotective property and pretreatment of the extract is beneficial in prevention of gastric ulcer.

  4. Metformin v/s glibenclamide: for intial therapy of type 2 diabetes mellitus in a tertiary care hospital, a comparative study, for efficacy and tolerability Download Article

    Dr. Syed Wasif, Dr. Ashfaq Ahmed
    • Type: Research Article
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    • Pages (23-32)
    • No of Downloads: 61

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    Background

    Diabetes mellitus is one of the most common non-communicable disease world-wide. There are many groups of drugs available for the treatment of type 2 diabetes mellitus. we use so many drugs as monotherapy or in combination to maintain normoglycemia. Because of paucity of published reports in the Indian literature regarding the pattern of use, efficacy, safety, tolerability of comparison of therapy of metformin and glibenclamide, the present study was taken up.

    Objectives

    To study the comparison of efficacy, safety and tolerability of metformin and glibenclamide in achieving normal blood glucose level in type 2 diabetes mellitus.

    Materials and methods

    100 properly selected subjects with type 2 diabetes mellitus were included for the present study. The medication were used empirically as monotherapy  OD or BID in a continuation manner after the meals. Blood glucose level was measured at the baseline and daily afterwards for one month using standard techniques. The data collected was analyzed statistically using descriptive statistics. Tolerability and patient compliance for the prescribed medications were also assessed during the follow up visits.

    Results

    Methformin  therapy reported to control the blood glucose level more efficiently as compared to glibenclamide at the end of the study,  as 84% of subjects showed normoglycemia as compared to glibenclamide (68%). Also, incidence of hyperglycemic episodes were less in metformin therapy.  Subjects with metformin therapy reported some what more side effects compared to glibenclamide  therapy. The patient compliance for the prescribed medications was excellent.

    Interpretation and conclusion

    Blood glucose level can be effectively maintained under normal limits in Type 2 DM, with metformin therapy as compared to glibenclamide.

  5. An observative study of comparison between non-antibiotic and with antibiotic treatment of acute diarrhea in a tertiary care hospital Download Article

    Dr. Syed Wasif, Dr. G.B.Doddamani
    • Type: Research Article
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    • Pages (33-41)
    • No of Downloads: 23

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    Background

    Acute diarrhoeal diseases rank among one of the most common infectious disease in almost all age groups worldwide.. Antibiotic therapy is not recommended for the treatment of diarrhoea routinely, only severe cases should be treated with a suitable antibiotic. Because of paucity of published reports in the Indian literature regarding the pattern of use of antibiotics in treatment of acute diarrheal cases, the present study was taken up.

    Objectives

    To study the comparison of treatment of acute diarrheal cases with or without antibiotic, in terms of outcome, safety and tolerability.

    Materials and Methods

    100 properly selected subjects with acute diarrhea were included for the present study. The medications were used orally or intravenously for 5-7 days, depending upon the particular case. The treatment outcome was assessed by noting number of diarrhea and vomiting episodes, pulse, blood pressure, weight and skin pinch of the patient from day 1 till the infection resolve completely. The data collected was analyzed statistically using descriptive statistics. Tolerability and patient compliance for the prescribed medications were also assessed during the follow up visits.

    Results

    Most of the subjects showed complete resolution of episodes of diarrhea and vomiting, with normalization of blood pressure by 2nd day and all subjects by end of 5th day with a minor majority in non-antibiotic treatment.

    Interpretation and Conclusion

    The acute diarrheal cases can be effectively treated by empirical use of non-antibiotics medications itself. Antibiotics are reserved for particular cases only.

  6. Study on the prevalence of asymptomatic bacterial vaginal infections in pre and post menopausal diabetic women Download Article

    N. Rajkumar, G. Shanthi and S. Selvakumar
    • Type: Research Article
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    • Pages (42-48)
    • No of Downloads: 51

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    Vaginal infections including candidal vaginitis and bacterial vaginosis collectively represent perhaps the most common affliction in pre menopausal women. Type 2 Diabetes is another very important cause for increase in the occurrence of vaginal infections in the pre menopausal age group. Objectives of the present study on the prevalence of bacterial vaginal infections in asymptomatic pre and post menopausal diabetic women. The samples from the 50 diabetic and non diabetic pre and post menopausal diabetic women were evaluated for the study from Dhanalakshmi Srinivasan Medical College Hospital, Siruvachur, Perambalur, Tamil Nadu from period of 2015 to 2016. Vaginal samples were taken from the patients during the period of surgical wound dressing before the wound was cleaned with antiseptic solution. The swab was examined by Gram staining, inoculated onto culture plates and incubated  aerobically and anaerobically. Antibiotic susceptibility pattern was performed by Kirby-bauer method. The pathogenic bacteria like E.coli, S. aureus were found to be more in diabetic women than the non diabetic women. C. albicans was found to be significantly more in diabetic women. In addition lactobacilli, Peptostreptococcus and Bacteroids were anaerobes commonly reported. Methicillin resistant S. aureus strains were found to be sensistive to Vancomycin. Gram negative isolates were highly sensitive to nitrofurantoin, amikacin and gentamicin.

  7. A review on pulmonary diseases Download Article

    Dr.L.Siddhartha, Bhavitha Kandru, Pravalika Dubasi, Sirisha Pullagurla
    • Type: Research Article
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    • Pages (49-54)
    • No of Downloads: 52

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    Lung diseases or pulmonary diseases are some of the most common medical conditions in the world. Lung disease affecting airways include asthma, chronic obstructive pulmonary disease. Lung disease affecting the air sacs include pneumonia, tuberculosis, pulmonary edema, lung cancer, acute respiratory distress syndrome, pneumoconiosis. Lung disease affecting the interstitium include interstitial lung disease. Lung diseases affecting blood vessels are pulmonary embolism, pulmonary hypertension. Lung disease affecting the pleura are pleural effusion, mesothelioma. Lung diseases affecting chest wall are obesity hypoventilation syndrome, neuromuscular disorder. Common symptoms include wheezing, shortness of breath, chest discomfort, cough with or without mucous, fever, blood in the sputum, weight loss, fatty stool. Diagnosis include pulmonary function test, chest imaging, thoracoscopy, needle biopsy pleura analysis, bronchoscopy, mediastinoscopy and mediastinotomy. Treatment for asthma, copd, pneumonia, bronchitis, include bronchodilators (salbutamol, theophylline), corticosteroids (hydrocortisone, prednisolone), antibiotics (amoxycillin, doxycycline, ciprofloxin, ceftriaxone) incase of tuberculosis medication include AKT3 & AKT4.

  8. Evaluate the anti-atherosclerotic activity of ethanol extract of Ochna obtusata DC. In the male wister albino rats by using High fat diet induced method Download Article

    Dasari Rajesh, N.S.Rama Raju, Garlapati Usha Kiran, P.Selvam, P.Partiban, N.Sriram
    • Type: Research Article
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    • Pages (55-71)
    • No of Downloads: 51

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    Latest trends have been increasing demand of phyto drugs and some medicinal herbs have proven to be potential in anti-hyper lipedemic activity. Medicinal herbs and extracts are prepared from them are widely used in the treatment of atherosclerosis. The compounds that are responsible for medicinal property of the drug are usually secondary metabolites. The whole plant of Ochna obtusata was collected from Tirumala hills, Tirupati, Andhra Pradesh. India. Ochna is a genus comprising 86 species of evergreen trees, shrubs and shrublets belonging to the family Ochnaceae. The collected whole plant was dried at room temperature, pulverized by a mechanical grinder, sieved through 40 mesh. About 100g of powdered materials were extracted with Ethanol (90%) using soxhlet apparatus. The animals were dosed with the test and the standard drugs orally based on the body weights of the animals. The animals were dosed with the extracts for about 14 days. After this time i.e., 20 hrs after the last application of the test compounds the animals are anaesthetized with anaesthetic ether and 1.2ml of blood is withdrawn by retro orbital puncture. The blood samples will be collected on the 14th day for estimating biochemical parameters.

  9. Experimental evaluation of antidiabetic activity of syzygium aromaticum extract in streptozotocin induced diabetic rats Download Article

    Ganesh Balram Saiprasanna, Balasubramaniyan Prathap and Sam Pavan Kumar
    • Type: Research Article
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    • Pages (72-76)
    • No of Downloads: 35

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    Diabetes mellitus is a globally prevalent chronic debilitating illness. The goals in management of diabetes are to alleviate symptoms and signs of hyperglycaemia, and to prevent or reduce the acute and chronic complications of diabetes. There are a range of oral hypoglycaemic agents available for the treatment of diabetes but they are costly and have many adverse effects which warrant the continued research for newer drugs. In the present study, the flower buds of Syzygium aromaticum was studied for its antidiabetic activity against Streptozotocin (55mg/kg, i.p) induced diabetes in rats. 50% of ethanol was used as solvent to extract the constituents of Syzygium aromaticum buds. Three dose levels of Syzygium aromaticum (100, 300 and 500mg/kg) were used in the study. The test drugs were administered once daily for 15 days and the mean body weight, blood sugar were measured on 0, 5, 10 and 15th day using Glucometer and percentage reduction in blood sugar levels were also determined.  All the doses of ethanolic bud extract of Syzygium aromaticum exhibited antidiabetic effect, but 500mg/kg showed significant antidiabetic effect as compared to other doses. From the result it was concluded that, Syzygium aromaticum exhibited antidiabetic effect against Streptozotocin induced diabetes in rats. Further studies are required to establish its anti-diabetic activity and to find out the exact mechanism for its anti-diabetic effect.

  10. Demographic profile in urinary tract infection Download Article

    Rushika S. Modi, Sagun V. Desai
    • Type: Research Article
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    • Pages (77-81)
    • No of Downloads: 43

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    Introduction

    Urinary tract infection (UTI) is the most frequent community-acquired infection worldwide between 1 year and 50 years of age. UTI and recurrent UTI are predominantly disease of females. In uncomplicated UTIs, E. coli is the leading organism, though other bacteria, viruses or fungi may be the cause.

    Methodology

    In present study 212 patients included from Medicine, Surgery and Obstetrics & Gynaecology Department over one year period.

    Result

    Total 55.18% patients were in age group of more than 18 years up to 35 years. 66.98% were female patients. Average per capita per month income was 1516.80 ± 319.31. The mean hospital stay was 3.99 ± 1.07 days. 95.28% patients had acute UTI, 83.96% had uncomplicated UTI and 91.03% had lower UTI. 53.77% patients had uncomplicated lower UTI. 19.33% antenatal patients had UTI. Overall Escherichia coli accounted for 80.95% of all isolates.

    Conclusion

    The choice of empirical initial antimicrobial therapy is significantly affected by uropathogen prevalences according to age, gender and socioeconomic status.

  11. Drug utilization study in urinary tract infection in a tertiary care hospital: a prospective study Download Article

    Rushika S. Modi, Sagun V. Desai
    • Type: Research Article
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    • Pages (82-86)
    • No of Downloads: 33

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    Introduction

    Urinary tract infection (UTI) is one of the most common infections in outpatients setting as well as in acute and long term care hospital patients. Successful treatment and prevention of recurrence of UTI require bacteriological identification, its sensitivity to antimicrobials, selection of appropriate antimicrobials and their appropriate application.

    Methodology

    In present study 212 patients have been included from Medicine, Surgery and Obstetrics & Gynaecology Department over one year period.

    Result

    Each patient have been given on an average 1.68 ± 0.77 and 0.86 ± 1.04 medicines by branded and generic names. Fluoroquinolones were the most commonly used antibacterials followed by cephalosporins. 47.13% medicines were listed in the 19th model list of essential medicines (WHO, 2015). 89.64% medicines prescribed rationally. All 541 (100%) medicine uses were found to be appropriate or most appropriate.

    Conclusion

    Fluoroquinolones and cephalosporins were the most commonly prescribed antibiotics. The need to adhere to standard treatment guidelines and prescribing from the essential drug list, using generic names have to be impressed upon treating physicians. 

  12. Study of prescription pattern in the management of herpes zoster at brims hospital, bidar Download Article

    Savitha.A , Kashinatha Gumma
    • Type: Research Article
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    • Pages (87-96)
    • No of Downloads: 28

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    Aim & Objectives

    1. To study the prescription patterns in Herpes Zoster cases in BRIMS Tertiary Hospital. 2. To assess the efficacy, tolerability and adverse drug reactions of the drugs used in treatment of Herpes Zoster.  

    Materials and Methods

    This was a prospective study conducted on both outpatients and inpatients of BRIMS Tertiary Hospital, Bidar, from 11-8-2014 to 12-08-2015 on patients with herpes zoster attending Department of Dermatology. A total of 90 patients with herpes zoster who presented within 72 hours of the onset of rash were enrolled in the study and randomized into three groups of 30 each of whom 30 patients assigned Valacyclovir 1000 mg TID, 30 patients were assigned Acyclovir 800 mg five times a day and Famciclovir 250 mg BD for 7 days. The treatments were given for 7 days. Patients were periodically followed up till day 29 to assess the effect of the drugs on the rate of resolution of pain, cessation of abnormal sensations, rate of rash healing, new lesion formation and occurrence of complications.

    Results

    The pain scores (measured by VAS) between the groups were compared and a significant reduction was observed in Valacyclovir group day 22 (P=0.013) and day 29 (P<0.0004). A significantly greater proportion of patients in Valacyclovir group did not have Zoster associated pain at day 29 (P=0.003). All the three drugs showed significant reduction in pain scores within the group between 2 consecutive visits. This trend was persistent throughout the study period. The rate of cessation of abnormal sensations, rash healing, new lesions formation and occurrence of complications was similar in three groups. Adverse events were infrequent and mild in nature. Headache, nausea, vomiting and abnormal pain were reported which did not warrant discontinuation and withdrawal from the study.

    Conclusion

    In the management of HerpesZoster the reduction of pain was best with Valacyclovir better with Famciclovir and least in Acyclovir. Other than resolution of pain which is faster with Valacyclovir than compared to Acyclovir and Famciclovir, there is no difference in outcome of rash healing, abnormal sensation and adverse effect with three drugs.

  13. A study on prescribing pattern of drugs prescribed in patients of acute myocardial infarction admitted in ICCU at a tertiary care hospital Download Article

    Dr. Purvi. J. Tanna, Dr. Priyanka. P. Hotha, Dr. Shrijikumar. C. Thakkar
    • Type: Research Article
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    • Pages (97-104)
    • No of Downloads: 29

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    Background

    Studies on prescription pattern have important value in the health set up and eventually provides insight into the efficiency of drug use and results of such research studies can be helpful to set priorities for the rational and effective use of medicines. Acute Myocardial Infarction (MI) is the main Congestive Heart Disease which has high morbidity and mortality and despite having the specific guidelines of treatment various drug therapy is still underused so study on prescription pattern of drugs used in Acute MI will provide us specific knowledge regarding prescription in such patients

    Aims and objectives

    Study was conducted to study the pattern of prescription and to analyze various group of drugs and specific drugs used in Acute MI.

    Material and methods

    A prospective, non interventional, single centre, observational study was conducted on 100 acute MI patients admitted in ICCU at G.G Hospital, Jamnagar for the duration of one year and all the demographic details and medication records were noted in case record form for each patient.

    Results

    Out of 100 patients, 82% patients were males and maximum e.g.45% were of age > 60 years. The percentages of patients who received Antiplatelet Agents, Thrombolytics, Beta Blockers, ACE inhibitors, Calcium Channel Blockers, Antianginal Drugs, Hypolipidaemics, Opioids,  and Antacids were 97%, 43%, 22%,78%, 15%, 55%, 84%, 73%, and 81%  respectively. Prescription of drugs per encounter was 9.38% with dominance of generic prescription.

    Conclusion

    Present study provide us with precious insight regarding pattern of drug used in patients of acute MI. Rational drug use with Generic prescription is needed for effective treatment.

  14. Terminalia catappa: A potential herb to promote hair growth, preliminary preclinical study Download Article

    Harsha Vardhan K and Jaikumar S
    • Type: Research Article
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    • Pages (105-108)
    • No of Downloads: 23

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    Hair loss problem is of great significance to both men and women. The essential issues associated with hair loss are hair fading, dandruff, and falling of hair. Alopecia is the medical term for hair loss or baldness. It is an embarrassing condition for any person as he/she looks extra aged than ordinary. Many forms of medication are available to treat alopecia in special procedure of medication such as Allopathic, Homeopathic, and Ayurveda or can also be surgical like hair transplantation; however, none of them is wholly ample. This hindrance could be solved by the use of natural medicines obtained from herbs. Terminalia catappa Linn belongs to the family Combretaceae and is popularly known as ‘deshi badam’. It is a well known herb in Ayurvedic system of medicine. Almost all the parts of Terminalia catappa were significantly employed in various ailments. The seed extract of  Terminalia catappa was claimed to have hair growth promotion property. Current study was conducted with an aim to evaluate the hair growth promotion activity of ethanolic seed extract of Terminalia catappa. The extract was mixed in coconut oil, applied on the shaved area of rats and qualitative hair growth analysis was undertaken by observing hair growth initiation time (Minimum time taken to initiate hair growth on denuded skin region), hair growth completion time (Minimum time taken to completely cover the denuded skin region with new hair) and mean hair length were measured. 2% Minoxidil was used as reference control and all the test drugs were applied once daily for 30 days. Ethanolic seed extract of Terminalia catappa significantly decreased the time taken for initiation of hair growth and hair growth completion time. Terminalia catappa significantly increased mean hair length size compared to vehicle treated. From the result it was concluded that Terminalia catappa promotes the hair growth in animal model.

  15. Antimicrobial utilization study in the department of surgery in a tertiary care teaching rural hospital Download Article

    Rushika S. Modi, Rushabh Somani
    • Type: Research Article
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    • Pages (109-113)
    • No of Downloads: 16

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    Introduction

    The purpose of surgical prophylaxis is to reduce the incidence of surgical site infection (SSI) with minimal alteration of normal microbial flora of the host and minimal adverse effects.

    Methodology

    In present study 200 patients have been included from Surgery Department over six month period.

    Result

    The common antimicrobials prescribed were third-generation cephalosporins (90.5%), followed by aminoglycosides (58%). Commonly prescribed individual antimicrobial agents were amikacin (58%), ceftriaxone (45%), metronidazole (40%) and cefixime (13%) and the common combination used were amoxicillin + clavulinic acid (21%), cefoperazone + sulbactam (18%), ofloxacin + ornidazole (16%), ceftriaxone + sulbactam (12.5%) and piperacillin + tazobactam (11%).

    Conclusion

    Cephalosporins and aminoglycosides were the most commonly prescribed prophylactic antimicrobial agents. Prophylactic antimicrobial agents should be prescribed appropriately using standard guideline.

  16. A prospective study on the efficacy of two drug combination chemotherapy in patients with malignant gonadal germ cell TUMORS Download Article

    Dr. Sudha. R, Dr.R. Navajothi, Dr.P.K.Muthukumara Samy
    • Type: Research Article
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    • Pages (114-120)
    • No of Downloads: 22

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    Malignant gonadal germ cell tumors are the rare malignant tumors which occurs in young individuals at the peak of their reproductive life between 18- 45yrs. Germ cell tumors are sensitive to chemotherapy as well as radiotherapy . Three and four drugs regimen  increases the survival of 80-90% with increased drug induced toxicity. This study is to find out the efficacy of two drug regimen with cisplatin and etoposide response in malignant gonadal germ cell tumor . The study was carried out in a tertiary care hospital for a period of 21 months. Twenty six patients were selected and six patients were excluded. Prior to treatment all patients were evaluated with basic investigations. αFP and β HCG levels were estimated before and after chemotherapy. Cisplatin 20mg /m² and Etoposide 75mg/m² was given daily for five consecutive days at an interval of 21 days in four cycles. Patients were observed for adverse effects during the course of therapy. Response was evaluated by  evidence of regression of the documented tumors and  measuring serum tumor markers  level . In this study 85% of patients were complete responders and side effects also less during treatment and the follow up period. 5% were partial responders and 10% were non responders. Partial and non responders were recommended for an alternative therapy.

  17. Prospective study on the effect and outcome of injection adrenaline administration during cardiopulmonary resuscitation Download Article

    Dr. Sudha. R, Dr. Vignesh Prabakaran
    • Type: Research Article
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    • Pages (121-126)
    • No of Downloads: 23

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    Adrenaline is a recommended drug in advanced life support protocol algorithm. This study is to find out the effect and outcome of adrenaline administration during cardiac resuscitation in a tertiary care centre. This study was carried out over a period of two months. Fifty one patients in the intensive care unit were included in this study. During cardiac resuscitation after defibrillation inj.adrenaline 1mg was given intravenously in 3 to 5 minutes of interval with maximum of two doses. Only two patients were revived successfully with cardiac resuscitation .This prospective observational study concludes diabetes and hypertension are the high risk factors for coronary artery disease. Males are predominantly affected and sedentary life style in females are under high risk. Earlier administration of adrenaline in shockable rhythm resulted in a worst outcome. Large study group population in future would clarify the reasons for poor outcome.