Articles

  1. In vivo Antimalarial Activity of Areal Part Extracts of Gardenia lutea and Sida rhombifolia Download Article

    Baye Akele
    • Type: Research Article
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    • Pages (234-241)
    • No of Downloads: 1556

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    Malaria is an endemic disease which affects 40% of world’s population and it is distributed widely, mainly due to the multi-drug resistance developed by Plasmodium falciparum. It remains the leading cause of death among parasitic diseases. Resistance to all known antimalarial drugs, except for the artemisinin derivatives, has developed to various degrees in several countries. Hence, there is a huge demand to develop antimalarial drug. In line with this notion, the hydroalcoholic leaves extracts of Gardenia lutea and Sida rhombifolia were tested for their in vivo activity against Plasmodium berghei. The extracts showed significant antimalarial activity at doseof 200400 and 600mg/Kg. The plant extracts also exhibited safety profile at tested doses of 500, 1000 and 2000mg/Kg. To conclude, 80% methanol extracts of Gardenia lutea and Sida rhombifolia exhibits significant antimalarial activity with acceptable margin of safety.  

    KEY WORDS: Antimalarial, Gardenia lutea, Sida rhombifolia, and safety.

  2. Effect of ethanolic extract of Piper nigrum Linn. fruits on pharmacodynamics of atorvastatin in rats Download Article

    Md.Parvez, S.Mounika, Md.Gayasuddin, K.Sudha Rani, Sumayya Samreen M.Soumya
    • Type: Research Article
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    • Pages (242-247)
    • No of Downloads: 1598

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    Herb-drug interaction about oral antihyperlipidemic drugs is a challenging concept, since the consumption of food and other herbal drugs is not documented in patient’s profile. With this aspect, the present study was designed to investigate the possible effect of Ethanolic extract of Piper nigrum Linn. fruits on Atorvastatin an oral antihyperlipidemic drug. The study was carried out to investigate the pharmacodynamics of atorvastatin (AT) alone, and in combination with Ethanolic extract of Piper nigrum Linn. fruits and Isolated Piperine in hyperlipidemic rats. The standard cholesterol diet was used to induce hyperlipidemia in Wister rats. The blood samples were collected (on 1st and 8th day) from AT alone and in combination with Extract (100mg/kg) treated and piperine (10mg/kg) treated groups and were analyzed for various lipid profiles. Atorvastatin caused a marked reduction in the lipid profiles in hyperlipidemic rats. The combination of AT and Piper nigrum Linn. fruits in hyperlipidemic rats produced a significant change in lipid profiles (pharmacodynamics). In this study, we investigated the effect of Ethanolic extract of Piper nigrum Linn. fruits on the efficacy of Atorvastatin (substrate for CYP3A4) in rats. These results suggest Piper nigrum Linn. fruits ingestion increases the efficacy of Atorvastatin by inhibiting intestinal CYP3A4 enzyme in albino wistar rats.

    Key words: Atorvastatin, Piper nigrum, pharmacodynamics. 

  3. Bambusa arundinacea (vanshlochan): An overview Download Article

    Ajay Kumar Rathaur.
    • Type: Review Article
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    • Pages (248-255)
    • No of Downloads: 1582

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    Bamboo species are thought to be originally from Central China, but are now found in many temperate and semi-tropical regions around the world. There are approximately 75 species and 200 varieties of Phyllostachys. Bambusa arundinacea (Vanshlochan) belonging to family Poaceae, is a well known Ayurvedic and medicinal plant in Indian tradition. This plant is reported to possess antidiabetic, antifertility, antibacterial, anti inflammatory and antiulcer, protective, anthelmintic, insecticidal, antiarthritic, antioxidant, aphrodisiac, vessel protection and venotonic activities. It is found in North-West India and Bengal, Sri Lanka, Malaya, Peru and Myanmar (Burma). Many of the important chemical constituents are found in it. It is a common plant which is mostly used as a building material ranging from food containers, skewers, chopsticks, handicrafts, toys, furniture, flooring, pulp and paper, boats, charcoal, musical instruments and weapons. In addition to its more common applications, bamboo has other uses, from skyscraper scaffolding and phonograph needles to slide rules, skins of airplanes, and diesel fuels. Bamboo ashes are used to polish jewels and manufacture electrical batteries. It has been used in bicycles, dirigibles, windmills, scales, retaining walls, ropes, cables and filament in the first light bulb.

    Key word: Bamboo, Bambusa arundinacea, Traditional medicinal use of bamboo.

  4. Review on Urinary Tract Infections In Renal Transplant Recipients Download Article

    S.Sriram, R.Palaniswamy, R.Vidhya.
    • Type: Review Article
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    • Pages (256-262)
    • No of Downloads: 1239

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    Solid organ transplantation is a therapeutic option for many diseases. Many opportunistic pathogens have been reported in solid organ transplantation recipients. Infections occurring after transplantation account for half the deaths in post transplant patients. Hence a thorough understanding of the technical aspects of transplantation is essential when caring for patients with infectious disease. Renal transplant recipients have a greater incidence of urinary tract infections occurring after hospital discharge and it remains a major problem despite advances in organ transplantation. Pathogens causing urinary tract infections in renal transplant recipients include enterococci, staphylococci, P. aeruginosa, and enteric gram-negative bacteria. There is an increasing trend towards antimicrobial resistance patterns among bacteria. Prophylaxis with trimethoprim-sulfamethoxazole reduces the incidence of bacterial infection of the urinary tract and bacteremia. Ciprofloxacin also provides effective prophylaxis for UTI. Colistin was found to be the drug of choice in ESBL producing organisms. Antibiotic prophylaxis should cover both gram-positive and gram-negative organisms. For uncomplicated renal transplantation irrigate the bladder prior to beginning the operation with a topical antibiotic solution such as Neomycin or Bacitracin. Cefazolin is administered intravenously. Antibiotics such as Piperacillin / Tazobactam and Ticarcillin cover a wide range of organisms including gram-positive, anaerobic, and gram-negative species.  Common choices for UTI include, Trimethoprim sulfamethoxazole, Ciprofloxacin, Cephazolin and Ampicillin. A detailed understanding of infections in renal transplant recipients is essential to prevent and treat these infections. Infections may be prevented by pre-transplant vaccinations, along with prophylactic medications, monitoring and behavior modification.

    Keywords: Urinary Tract Infections, Renal Transplant, Antibiotics, Prophylaxis.

  5. Effect of Hydroalcoholic extract of Baliospermum montanum roots against diabetic nephropathy on rats. Download Article

    S.Mohanraghupathy, P.Silambujanaki, V.Chitra, D.Raju.
    • Type: Research Article
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    • Pages (263-266)
    • No of Downloads: 1685

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    Baliospermummontanum is a plant possessing medicinal properties. The test sample was prepared by extracting the material using Soxhlet apparatus taking ethanol and water in 7:3 ratio. In this study, the anti-diabetic effect on oral administration of hydro alcoholic extract of Baliospermummontanum plant root at the dose of 100mg/kg, 200mg/kg on Streptozotocin (STZ) induced diabetic rats has been studied. The treatment was assessed by measuring the blood glucose levels for once in three weeks. The extract was given continuously for 40 days. Then at the 39th day urine was collected by placing the rats in metabolic cages for 24 hours. Then on 40th day blood samples were collected from retro-orbital plexus. After collection of samples biochemical parameters like serum albumin, cholesterol, total protein, creatinine and blood urea nitrogen were measured using various kits with the help of semi auto analyser. The investigated results showed that the extract inhibited the STZ induced diabetes in a dose dependent manner and this effect was more significant with 200mg/kg dose. The reports showed that reduced blood glucose levels in the animals. And also serum levels of cholesterol, blood urea nitrogen, creatinine and urine samples albumin and total protein were also reduced. The results suggest that the hydro alcoholic extract of Baliospermummontanum at a dose of 200 mg/kg exhibits significant effect on diabetic nephropathy.

    Key words: Diabetic nephropathy, Baliospermummontanum, Streptozotocin 

  6. A Review on Alternative Therapy for Acne Download Article

    Swalin Parija, Sunil Kumar Kanungo, Sudhansu Ranjan Swain
    • Type: Review Article
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    • Pages (267-273)
    • No of Downloads: 2308

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    Acne is the cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production, and it is characterized by both inflammatory (papules, pustules and nodules) and noninflammatory (comedons, open and closed) lesions. Propionibacterium acnes and Staphylococcus epidermidis are common pus forming microbes responsible for the development of various forms of acne vulgaris. A number of factors contribute to the development of acne lesions these include internal hormones, bacteria, some medications, certain chemicals/products that come in contact with the skin, local pressure to the skin surface, and stress. Traditionally, attention has focused mostly on over-production of sebum as the main contributing factor of acne. More recently, more attention has been given to narrowing of the follicle channel as the second main contributing factor. Common therapies that are used for the treatment of acne include topical, systemic, hormonal, herbal, and combination therapy. Topically used agents are benzoyl peroxide, antibiotics and retinoids. Systemically used agents are antibiotics and isotretinolin. While acne cannot be cured, it can be controlled. The goal of treating acne is to reduce the symptoms and to prevent permanent scarring.

    Key words: Acne, Papules, Pustules, Nodules, Propionibacterium acnes, Staphylococcus epidermidis.

  7. Pharmacological Evaluation of Laxative effect of Ageratum conyzoides L. on experimental albino rats Download Article

    Sathyanathan.V, Satish Gunda, Eswar kumar.A, Shubhrajit Mantry, L.R.Thilothama.
    • Type: Research Article
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    • Pages (274-278)
    • No of Downloads: 2408

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    The purpose of the present study was to evaluate scientifically the laxative effect of ethanolic extract of whole plant of Ageratum conyzoides L.(EEAC) on experimental albino rats. The laxative effect was expressed as the faecal output and faecal count/frequency at 8h and 16h.  EEAC at the doses of 200 mg/kg (P<0.05) and 400 mg/kg (P<0.01), significantly increased the faecal output in albino rats. The results obtained establish the efficacy and substantiate the folklore claim as a laxative agent. Further studies are needed to completely understand the mechanism of laxative effect of Ageratum conyzoides L.

    Keywords: Ageratum conyzoides L., Laxative activity, Traditional medicine, Agar-agar, Faecal output.

  8. Protective effect of an adenosine receptor agonist on neuropathic pain using chemotherapy induced neuropathy in mice. Download Article

    Vishweswar Rao.V, Sumadhuri Sreerama, Sowjanya Kumar Reddy.R, Santosh.M.
    • Type: Research Article
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    • Pages (279-285)
    • No of Downloads: 1488

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    Neuropathy is defined as the pain condition that results from damage affecting peripheral nerves, posterior roots, spinal cord or certain regions of brain. Increased neuronal excitability is thought to be the underlying mechanism for all forms of painful neuropathies. The work was framed to study the adenosine based treatment for chemotherapy induced neuropathy. Involvement of adenosine in nociception created an interest to work for chemotherapy induced neuropathy. Tricyclic antidepressants (TCAs), though often the first choice in most patients causes sedation and cardiovascular issues, Anticonvulsants, like the TCAs, are only partially effective in the majority of patients,  Opioids, though often prescribed for moderate to severe pain, are sometimes avoided because of their potential for dependence and tolerance, scheduling issues and side effects. Hence in order to overcome these side effects we made an attempt to develop a newer drug for the treatment. Mice were first treated with vincristine sulphate (100 µg/kg, i.v). A single intravenous dose of vincristine causes painful peripheral neuropathy. Then we administer drugs for five days after inducing neuropathic pain. Baseline and 5 days after induction of neuropathic pain hyperalgesia (mechanical) and allodynia (mechanical) of all groups were measured in order to confirm the development of neuropathic pain. Hyperalgesia and allodynia of drug treated group was compared on 5th day with vehicle treated group in order to confirm the effectiveness of drug in neuropathy pain. Hence adenosine was found to be significant against neuropathic pain in lower and also in higher dose. Hence adenosine may provide a better insight in the development of the newer drug for neuropathic pain.

    Key words: Neuropathy, Adenosine, Chemotherapy.

  9. Estimation of flavonoid, phenolic content and free radical scavenging activity of fresh unripe fruits of lantana camara linn (verbenaceae) Download Article

    Vedavathi T, Bhargavi K, Swetha G, Mythri K.
    • Type: Research Article
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    • Pages (286-294)
    • No of Downloads: 1437

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    The Lantana camara Linn (verbenaceae) is available throughout world as a weed. The genus Lantana includes 2500 species worldwide and is known for its bioactive secondary metabolites and essential oils. It is used for the treatment of various disorders. The therapeutic effects of tannins and flavonoids can be largely attributed to their free radical scavenging property and it is responsible for many pharmacological activities.  The present study is designed for the extraction of fresh unripe fruits using alcohol (cold, hot and micro wave techniques). The extracts were investigated for phytochemicals, total phenolic components, flavonoidal content and in-vitro free radical scavenging property (DPPH–RSA method).  The preliminary phytochemical investigations revealed that presence of glycosides, alkaloids, carbohydrates, flavonoids, inuline, tannins (phenolic compounds). The total Phenolic content of alcoholic extracts (cold, hot and micro wave) showed the content values of 4.67±0.22% w/w, 6.92±0.41% w/w and 7.291±0.13%w/w and total flavonoids estimation of alcoholic extracts (cold, hot and micro wave methods) showed the content values of 5.12±0.08% w/w, 6.623±0.32%w/w and 7.458±0.24%w/w for Quercetin respectively. Further investigation were carried out for In-vitro free radical scavenging assay by calculating its % inhibition by means of IC50 values, all the extracts concentration has been adjusted to come under the linearity range and here many reference standards like Tannic acid, Quercetin, Ascorbic acid have been taken for the method suitability. The results revealed that fresh unripe fruits of this plant have free radical scavenging potential. Among these results alcoholic extract by micro wave technique has more yield and more potent than other extraction methods. In conclusion that the Lantana camara Linn. (Verbenaceae) fresh unripe fruits possesses the antioxidant substance which may be potential responsible for the treatment of tumors and rheumatism and other oxidative stress related diseases.

    Keywords: Lantana camara Linn. (Verbenaceae), Total phenolic content (TPC), Total flavonoid content (TFC)radical scavenging assay (DPPH – RSA)

  10. Phytochemical screening and in-vivo evalution of anti diabetic studies of an ayurvedic herbo mineral formulation trushanaadiloha. Download Article

    K.V. RamSubbarao, M.L. Naidu
    • Type: Research Article
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    • Pages (295-299)
    • No of Downloads: 2513

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    The Herbomineral formulation Trushanadi loha is a mixture of fourteen drugs. All drugs used in this formulation are from different parts of plant sources. The mixture of different 14 drugs was extracted with aqueous and evaluated for Anti diabetic activity.  40 % reduction in blood glucose levels was observed and found the herbomineral formulation produced significant reduction in blood glucose of normal rats.

    Key words: Anti Diabetic activity, Trushanadiloha, Aqueous extract, Herbo mineral formulation.

  11. A Comparison of Intranasal Dexmedetomidine and Midazolam for Premedication in children - A prospective randomised double blind controlled trial Download Article

    Prabhu Thilaak, J.Ranganathan, P.Srinivasan, SreeSabari.S.
    • Type: Research Article
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    • Pages (300-306)
    • No of Downloads: 1556

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    In children, preanesthetic medications are administered to alleviate the stress and fear of surgery, to ease child-parent separation and to promote a smoother induction of anesthesia. Midazolam is a commonly used drug for this purpose. Clonidine, an 2 agonist, has been suggested as an alternative. Dexmedetomidine is a more 2 selectivedrug than clonidine and has favourable pharmacokinetic properties. The sedation produced by dexmedetomidine differs from other sedatives in that the patients are easily aroused and are cooperative. Intranasal administration of preanaesthetic medications is relatively easy and gives a high bioavailability of the drugs than oral route. We compared intranasal dexmedetomidine with intranasal midazolam for premedication in children. We conclude that children premedicated with 1 µg/kg of intranasal dexmedetomidine attained more significant and satisfactory levels of sedation at parental separation and at induction of anesthesia than those patients who received 0.2mg/kg of intranasal  midazolam. The change in behaviour produced is favourable and is similar with both drugs. The changes in heart rate and blood pressure observed with intranasal dexmeditomidine are clinically insignificant and are manageable.

  12. Comparative Study of the Efficacy and Tolerance of Prokinetic Drugs – Metoclopramide and Cinitapride In the Treatment of Functional Dyspepsia – A Randomized Controlled Trial. Download Article

    Dr.P.Swarupa Rani, Dr.Vasundara Devi, Dr.Sharon Sonia, Dr.Rajesh.
    • Type: Research Article
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    • Pages (307-313)
    • No of Downloads: 1418

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    To assess the Comparative Efficacy of a Novel Gastro Prokinetic Drug Cinitapride in relation to the time tested prokinetic agent Metoclopramide in an ambulatory setting of 6weeks duration in functional dyspepsia patients defined by using Rome III Criteria. Patients were stratified according to the predominant clinical symptoms like Epigastric pain, Post prandial fullness and early satiety.  Of the total 60 patients, 27 patients were categorized as EPS Group (Epigastric Pain Syndrome) (14 –Metoclopramide Group and 13 in Cinitapride Group), 33 patients were assigned to PDS Group (Post prandial Discomfort Syndrome) (16-MTP & 17-CTP).  Of the 60 patients Metoclopramide (MTP) and Cinitapride (CTP) were administered to two groups, 30 each in random fashion. Necessary statistical assessment and analysis were done after a period of 6 weeks. EPS is Predominant in males – 52%, PDS in females – 55% Age distribution showed 71.67% of patients falling in the age group of >30yrs. In male patients CTP is more efficacious than MTP. In female patients also, the same finding was observed but it is not statistically significant (P>0.05). Among both males and females CTP is more efficacious than MTP.  The results have shown that CTP is superior to MTP, in symptom resolution of study population. Dysmotility patients responded well, compared to pain group in both drug populations. When adverse drug reaction profile of both drugs is statistically analyzed, CTP group showed very less side effects compared to MTP group during the study period of 6 weeks.  CTP proved to be a better drug than MTP in both efficacy and tolerability in functional dyspepsia cases.

    Key words: Functional dyspepsia, Rome III criteria, EPS, PDS, CTP, MTP.

  13. Anti Cancer activity of Cinnamomum Malabatrum against Dalton’s ascitic lymphoma Download Article

    Sorabh kumar agrawal, R.C.Chipa, K.C.Samanta Suresh.
    • Type: Research Article
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    • Pages (314-319)
    • No of Downloads: 1553

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    The aim of the research is to find out new anti cancer drugs from indigenous plant which are potent, nontoxic or minimal toxic and to investigate the anti cancer activity of Cinnamomum Malabatrum. The powder of Cinnamomum Malabatrum was successively Extracted with Petroleum Ether, Chloroform, Acetone, Ethyl alcohol and Aqueous .The preliminary phytochemical test were done and the LD50 values for both alcohol and aqueous  extract determined. The anti cancer activity of the alcoholic (625 mg / kg. p.o.) and aqueous Extract (500 mg / kg. P.O.) were assessed in Dalton’s Ascitic Lymphoma induced  cancer.

    KEY WORDS: Cinnamomum malabatrum, Delton,s ascitic lymphoma.

  14. Evaluation of clinical data of kidney stone: An attempt to find preferable drugs used in kidney stone: Results of the survey conducted in nashik district of maharashtra Download Article

    Raundal Mahendra J, Chaudhari Prafulla, Bhalerao Pratap, Suryawanshi Ravikiran, Barhate Shashikant, Bari Manoj, Nand Milan.
    • Type: Research Article
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    • Pages (320-323)
    • No of Downloads: 1389

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    Due to ocean by three sides and hot location, ratio of kidney stone in India is much more than western country. An open clinical survey was conducted to determine the most effective, efficient and tolerable drug used in kidney stone. In the survey, a total of 3 hospitals, 10 clinics, 10 medicals, 2 medical agencies and 100 patients with confirmed diagnosis of kidney stone were analyzed. The survey revealed the different drugs used in kidney stone in urban as well as rural area. It was found that though Cital syrup was preferred both in urban and rural area, Unani diuretic solution was used mostly in rural area. Drugs for other diseases like acidosis, pain were used with diuretic drug. They include Potrate solution and Dytor tablet respectively. In case of injections, Voveron injection was most common. The survey showed that the use of these drugs could achieve the recommended goals of expelling stone out of body and reducing the intensity of other related diseases like acidosis, pain etc.

    KEY WORDS: Kidney stone, Clinical data, Treatment of Kidney stone.

  15. In-vitro Antioxidant studies on ethanolic extracts of Boswellia ovalifoliolata and Saccharum spontaneum by DPPH, Nitric oxide and Lipid peroxidation methods. Download Article

    Geetha Kodali, Ganapaty Seru.
    • Type: Research Article
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    • Pages (324-330)
    • No of Downloads: 1480

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    Oxidative stress is currently suggested a mechanism underlying various degenerative disorders such as atherosclerosis, cancer, aging, diabetes and Alzheimer’s. Chemical principles from nature such as flavonoids and other phenolic compounds were reported to act as scavengers of free radicals that are continuously generated in the human body. The aim of the present study was to investigate the antioxidant properties of ethanolic extracts of Boswellia ovalifoliolata and Saccharum spontaneum. The antioxidant properties of the extracts were determined by scavenging 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH), Nitric oxide (NO) and lipid peroxidation (LPO). The results of in-vitro studies showed higher percentage of inhibition of free radicals by ethanolic extract of Boswellia ovalifoliolata and saccharum spontaneum in a concentration dependent manner. The antioxidant effect may be attributed to the presence of phenolic compounds in the extracts which were quantified by Folin-ciocalteau method. From the results obtained, it may be concluded that Boswellia ovalifoliolata and Saccharum spontaneum possess significant antioxidant activities.

    Key words: Boswellia ovalifoliolataSaccharum spontaneum, total phenolics, antioxidant, DPPH, Nitric oxide, Lipid peroxidation.

  16. Study on achievement of target LDL-C in Dyslipidemic patients Download Article

    V.Shivashankar, V.Aji, S.Sriram, B.Rajalingam, A.S.Manjula Devi, B.Chitra, D.Vidhya, N.V.Deepak
    • Type: Research Article
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    • Pages (331-335)
    • No of Downloads: 1494

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    Cardiovascular diseases are the leading cause of illness and morbidity in developing and developed countries. The majority of cardiovascular cases stem from atherosclerosis and epidemiological studies have identified dyslipidemia is the prime etiology for the atherosclerosis. A prospective observational study was conducted at a multispecialty hospital in the General Medicine and Cardiology departments for a period of 8 months.  The study was carried among 80 dyslipidemic patients. From the lipid profile data it was found that 15(18.75%) patients LDL-C found to be above optimum level, 5(6.25%) patients LDL-C found to be borderline high, majority of the patients 42(52.5%) were found to have high LDL-C levels and 18(22.5%) patients LDL-C was found to be very high. All the study population required drug therapy as per ATP III guidelines of NCEP. The majority of patients (95%) were receiving lipid lowering therapy with statins and rest of the patients was on combination therapy. The patients were categorized based on the risk factors, 40 (50%) as CHD group, 34 (42.5%) as high risk non CHD group and 6 (7.5%) belongs to low risk non CHD group. For the high risk non CHD group ten year risk percentage for having CHD was calculated and the results reveal that 3(8.8%) patients were found to have <10% of risk for CHD, 10(29.4%) patients has 10-20% of risk for CHD and 21(61.8%) patients have >20% of  risk for CHD. Based on the risk groups assessment of target LDL-C was performed and the results reveals that 22.5% of study population achieved the target LDL-C described by ATP III guideline, which was found to be unsatisfactory. The study results necessitates the need for more aggressive management is required to attain target LDL-C levels. The pharmaceutical care can be the key for successive lipid lowering therapy.

    KEYWORDS: Dyslipidaemia, Lipid profile, LDL-C goal, ATP III guidelines, Statins.

  17. Pharmacological evaluation of Anti inflammatory, Analgesic and Antipyretic activity of Bauhinia variegate stem bark Download Article

    *Krishnaveni Janapareddi, Swetha Jannapureddy, Manjula Pulluru, Sudheer K Dundigalla
    • Type: Research Article
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    • Pages (336-343)
    • No of Downloads: 1488

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    NSAIDs are one of the most widely used categories of drugs presently and there are many clinical situations where one needs to use them for fairly long periods. As a result of prolonged use, side effects especially gastric ulceration may worsen the clinical manifestations in the patient. Therefore there is a need to search for analgesics without the accompanying problems even after a prolonged use. A literature survey of herbs with analgesic and anti-inflammatory effects led to Bauhinia variegate which was quoted in the Ayurvedic literature as having many therapeutic activities some of them being analgesic and anti-inflammatory. Lot of research work is reported on this plant but the stem bark was not evaluated for analgesic and anti-inflammatory activities. A hydro ethanolic extract was prepared and evaluated for analgesic, anti-inflammatory and antipyretic activities using conventional pharmacological methods and animal models. The results indicated that the bark extract at a dose of 200mg/kg showed significant analgesic, anti-inflammatory and antipyretic activities compared to the control group.

    Key words: NSAIDs, Bauhinia variegata, analgesic, anti-inflammatory, antipyretic, stem bark